Triphenylphosphine → HCID 21077431, compound

HRID 1374658Notes

Reaction equation

HRID 1374658 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[N:15]=[C:14]([NH:16][CH3:17])[C:13]([NH:18][C:19]([N:21]([CH2:23][CH2:24]O)[CH3:22])=[O:20])=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[N:15]=[C:14]([NH:16][CH3:17])[C:13]([N:18]3[CH2:24][CH2:23][N:21]([CH3:22])[C:19]3=[O:20])=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

5

Reactant 3

HCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 10156898HCID 10156898, compound

Product 1

HCID 21077431HCID 21077431, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

300 mg of 2-(3,4-dichlorophenylamino)-4-methylamino-5-[[N-methyl-(2-hydroxyethyl)-amino]carbonylamino]-pyrimidine and 205 mg of triphenylphosphine in 6 ml of tetrahydrofuran are combined with 0.13 ml of diethyl azodicarboxylate and stirred overnight at ambient temperature. The reaction mixture is purified by chromatography through a silica gel column with ethyl acetate/methanol/conc. aqueous ammonia (19:1:0.5).

Workup

  1. customThe reaction mixture is purified by chromatography through a silica gel column with ethyl acetate/methanol/conc

Sources & evidence

ORD record
ord-3d6a6feed6b74cb1a466d77d35a07fd9
Source dataset
uspto-grants-2007_01
Patent number
US07166599B2

Reaction notes

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