Hydrochloric Acid → HCID 69414094, compound

HRID 1374667Notes

Reaction equation

HRID 1374667 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:31]=[CH:30][C:7]([CH2:8][NH:9][C:10](=[O:29])[C@@H:11]([NH:21]C(OC(C)(C)C)=O)[CH2:12][O:13][CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:6][CH:5]=1>O1CCOCC1>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][NH:9][C:10](=[O:29])[C@@H:11]([NH2:21])[CH2:12][O:13][CH2:14][CH:15]2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]2)=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 44305340HCID 44305340, compound

Product 1

HCID 69414094HCID 69414094, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Under cooling with ice, a solution of 4N solution of hydrogen chloride in dioxane (12 ml) was added dropwise to the compound prepared in Example 2 (1180 mg). The solution was warmed to room temperature and stirred for 1 hour. The reaction mixture was concentrated to give the title compound (920 mg) having the following physical data.

Workup

  1. temperatureUnder cooling with ice
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-a7d2b0c4971f4a4b8d4b362323dc3dba
Source dataset
uspto-grants-2007_01
Patent number
US07166590B2

Reaction notes

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