反应详情

温度

70 °C

5-Chloro-3-pyridinol (10.0 g) was dissolved in anhydrous N,N-dimethyl formamide (150 ml) containing anhydrous potassium carbonate (21.2 g) and methyl 2-bromobutyrate (16.4 ml). The mixture was stirred at 70° C. for 1.5 hours and allowed to cool to ambient temperature. The mixture was poured into water, extracted with diethyl ether (three times) and the combined extracts were washed with water (twice), dried over magnesium sulphate and evaporated under reduced pressure to give the required product as a pale brown oil, 27.4 g.

1. temperatureto cool to ambient temperature
2. extractionextracted with diethyl ether (three times)
3. washthe combined extracts were washed with water (twice),
4. dry with materialdried over magnesium sulphate
5. customevaporated under reduced pressure