Potassium Hydroxide → HCID 2757211, compound

HRID 1375053Notes

Reaction equation

HRID 1375053 reaction equation
C[O:2][C:3]([C:5]1[S:6][C:7]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)=[CH:8][C:9]=1[NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])=[O:4].[OH-].[K+]>C(O)C.O.Cl>[C:14]([O:13][C:11]([NH:10][C:9]1[CH:8]=[C:7]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[S:6][C:5]=1[C:3]([OH:4])=[O:2])=[O:12])([CH3:17])([CH3:15])[CH3:16]

Participants

6

Reactant 2

HCID 14797Potassium HydroxideHCID 69265690HCID 69265690, compound

Product 1

HCID 2757211HCID 2757211, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 1a (1.37 g, 3.73 mmol) in ethanol (20 mL) was mixed with KOH (627 mg, 11.2 mmol) in water (20 mL). The resultant mixture was heated at 60° C. for 1 h, diluted with HCl (50 mL, 1N) and extracted with ethyl acetate (60 mL, 3×). The combined organic phases were dried over MgSO4, filtered, and concentrated to afford compound 1b as a yellow solid.

Workup

  1. extractionextracted with ethyl acetate (60 mL, 3×)
  2. dry with materialThe combined organic phases were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-4c9e6cda97bb473f8f5c729ffca0b531
Source dataset
uspto-grants-2007_01
Patent number
US07166639B2

Reaction notes

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