反应详情

10 g of sodium acetylacetonate and 20 g of potassium carbonate in 50 ml of acetone were heated to reflux and 15 g of bromoacetic acid ethyl ester was added dropwise over 15 minutes. After refluxing for several days, the solid was filtered off and washed with petroleum ether and acetone. Fractional distillation yielded 6.4 g of 5-acetyl-6-oxo-heptanoic acid ethyl ester.

1. temperatureto reflux
2. temperatureAfter refluxing for several days
3. filtrationthe solid was filtered off
4. washwashed with petroleum ether and acetone
5. distillationFractional distillation