Acetone → HCID 10104678, compound

HRID 1375098Notes

Reaction equation

HRID 1375098 reaction equation
[CH3:1]/[C:2](/[O-:7])=[CH:3]/[C:4]([CH3:6])=[O:5].[Na+].C(=O)([O-])[O-].[K+].[K+].[CH2:15]([O:17][C:18](=[O:21])[CH2:19]Br)[CH3:16].[CH3:22][C:23](C)=O>>[CH2:15]([O:17][C:18](=[O:21])[CH2:19][CH2:22][CH2:23][CH:3]([C:2](=[O:7])[CH3:1])[C:4](=[O:5])[CH3:6])[CH3:16]

Participants

5

Reactant 4

HCID 180AcetoneHCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 6008486Sodium acetylacetonate hydrate

Product 1

HCID 10104678HCID 10104678, compound

Procedure

10 g of sodium acetylacetonate and 20 g of potassium carbonate in 50 ml of acetone were heated to reflux and 15 g of bromoacetic acid ethyl ester was added dropwise over 15 minutes. After refluxing for several days, the solid was filtered off and washed with petroleum ether and acetone. Fractional distillation yielded 6.4 g of 5-acetyl-6-oxo-heptanoic acid ethyl ester.

Workup

  1. temperatureto reflux
  2. temperatureAfter refluxing for several days
  3. filtrationthe solid was filtered off
  4. washwashed with petroleum ether and acetone
  5. distillationFractional distillation

Sources & evidence

ORD record
ord-fd4f3659e30945a68019c7444405d454
Source dataset
uspto-grants-2007_01
Patent number
US07166648B2

Reaction notes

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