Hydrochloric Acid → HCID 19789957, compound

HRID 1375108Notes

Reaction equation

HRID 1375108 reaction equation
C([O:5][C:6](=[O:25])[CH2:7][CH2:8][C:9]([C:22](=[O:24])[CH3:23])([C:19](=[O:21])[CH3:20])[CH2:10][CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])(C)(C)C.Cl>C(O)(C)(C)C.O>[C:22]([C:9]([C:19](=[O:21])[CH3:20])([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH2:8][CH2:7][C:6]([OH:25])=[O:5])(=[O:24])[CH3:23]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58784957HCID 58784957, compound

Product 1

HCID 19789957HCID 19789957, compoundYield 69%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6386tert-ButanolSolvent

Procedure

4,4-Diacetyl-heptanedioic acid di-tert-butyl ester was hydrolyzed at 95° C. over 5 hours using a mixture of tert-butanol and water as solvent and 11 weight-% hydrochloric acid. The solvent was removed and the obtained crude product was recrystallized from a mixture of acetone and petroleum ether (1:1) to yield 4,4-diacetyl-heptanedioic acid as white crystals at a yield of 69%. (melting point: 176° C.; purity 94%; colorless).

Workup

  1. customThe solvent was removed
  2. customthe obtained crude product
  3. customwas recrystallized from a mixture of acetone and petroleum ether (1:1)

Sources & evidence

ORD record
ord-e294c1218fe742abaf9d43a97e687522
Source dataset
uspto-grants-2007_01
Patent number
US07166648B2

Reaction notes

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