3-Hydroxybenzaldehyde → Salicylaldehyde

HRID 1375212Notes

Reaction equation

[C:1]([O-:6])(=O)[C:2]([CH3:4])=O.[OH:7][C:8]1C=C([CH:13]=[CH:14][CH:15]=1)C=O>>[OH:6][C:1]1[CH:2]=[CH:4][CH:13]=[CH:14][C:15]=1[CH:8]=[O:7]

Participants

Reactant 2

HCID 1013-Hydroxybenzaldehyde

HCID 107735Pyruvate

Product 1

HCID 6998Salicylaldehyde

Procedure

The reaction rate was measured as described in Example 1, using as substrates 5 mM pyruvate and 5 mM 3-hydroxybenzaldehyde. The absorbance values at 346 nm decreased linearly at a rate of 0.15 OD/min, which yielded a decrease of hydroxybenzaldehyde concentration 0.3 μmol/min, when using ε=480 M−1cm−1. The corresponding activity was 0.93 U/mg.

Sources & evidence

ORD record: ord-94f46f4f7e7f43c39b88b712c3c4d8a2
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07166749B2

Reaction notes

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