5-Methoxytetralone → HCID 3532765, compound

HRID 1375362Notes

Reaction equation

HRID 1375362 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][C:8]2=O.Cl.[NH2:15][OH:16].O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][C:8]2=[N:15][OH:16]

Participants

5

Reactant 3

HCID 366205-MethoxytetraloneHCID 443297Hydroxyamine hydrochlorideHCID 2735133Sodium Carbonate Monohydrate

Product 1

HCID 3532765HCID 3532765, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A solution of 5-methoxy-1-tetralone (5.0 g) in ethanol (100 mL) was treated with hydroxylamine hydrochloride (2.1 g) and sodium carbonate monohydrate (3.6 g). The reaction mixture was heated overnight at 80° C. with a condenser. Cooled to room temperature after approximately seventeen hours, transferred to another flask and concentrated. The residue was triturated in water and filtered to yield the title product as a beige solid (5.1 g).

Workup

  1. temperatureCooled to room temperature after approximately seventeen hours
  2. customtransferred to another flask
  3. concentrationconcentrated
  4. customThe residue was triturated in water
  5. filtrationfiltered

Sources & evidence

ORD record
ord-f9929831cfc14ca2bf7d891793b72f45
Source dataset
uspto-grants-2007_01
Patent number
US07169773B2

Reaction notes

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