Hydrochloric Acid → HCID 54711997, compound

HRID 1375548Notes

Reaction equation

HRID 1375548 reaction equation
C[O:2][CH:3](OC)[CH2:4][C:5]1[N:6]([CH3:24])[C:7](=[O:23])[C:8]([OH:22])=[C:9]([C:11]([NH:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[O:12])[N:10]=1.Cl>C1COCC1>[F:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][NH:13][C:11]([C:9]2[N:10]=[C:5]([CH2:4][CH:3]=[O:2])[N:6]([CH3:24])[C:7](=[O:23])[C:8]=2[OH:22])=[O:12])=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54712022HCID 54712022, compound

Product 1

HCID 54711997HCID 54711997, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product of Step 1 was treated with a mixture HCl 1N/THF for 1 hour at 40° C. Organics were removed in vacuo and residue extracted in DCM, dried over Na2SO4 and concentrated to give the title compound as a foam which was immediately reacted in the following reductive amination.

Workup

  1. customOrganics were removed in vacuo and residue
  2. extractionextracted in DCM
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-39368702e71c44bdb272a3f8c4e108b8
Source dataset
uspto-grants-2007_01
Patent number
US07169780B2

Reaction notes

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