Oxalyl chloride → HCID 9819702, compound

HRID 1375701Notes

Reaction equation

HRID 1375701 reaction equation
[CH:1]1([O:6][C:7]2[CH:8]=[C:9](/[CH:15]=[C:16](/[C:21]([O:23][CH3:24])=[O:22])\[CH2:17][C:18]([OH:20])=[O:19])[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:25](Cl)(=O)C(Cl)=O>C(Cl)Cl>[CH3:24][O:23][C:21](/[C:16](=[CH:15]/[C:9]1[CH:10]=[CH:11][C:12]([O:13][CH3:14])=[C:7]([O:6][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)[CH:8]=1)/[CH2:17][C:18]([O:20][CH3:25])=[O:19])=[O:22]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 58787775HCID 58787775, compound

Product 1

HCID 9819702HCID 9819702, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.67 g (0.005 mol) of (3E)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3-(methoxycarbonyl)-3-butenoic acid are suspended in 8 ml of methylene chloride. 0.36 ml of N,N-DMF (0.005 mol), are added under stirring at room temperature, the solution is cooled to 0° C. and 0.87 ml (0.01 mol) of oxalyl chloride is added.

Workup

  1. temperaturethe solution is cooled to 0° C.

Sources & evidence

ORD record
ord-281e6350ec764e808916a08394ccfdb3
Source dataset
uspto-grants-2007_01
Patent number
US07169808B2

Reaction notes

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