反应详情

N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinazolinyl)oxy]phenyl}-N′-propylurea (55 mg), potassium carbonate (20 mg), and 3-bromo-1-propanol (62 μl) were dissolved in N,N-dimethylformamide (4 ml), and the solution was stirred at room temperature for 3 hr. The solvent was removed by distillation under the reduced pressure. Water was added to the residue, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under the reduced pressure. The residue was purified by chromatography on silica gel by development with chloroform/methanol to give 25 mg (yield 40%) of the title compound.

1. customThe solvent was removed by distillation under the reduced pressure
2. additionWater was added to the residue
3. extractionthe mixture was extracted with chloroform
4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
5. customthe solvent was removed by distillation under the reduced pressure
6. customThe residue was purified by chromatography on silica gel by development with chloroform/methanol