Potassium Hydroxide → HCID 22499392, compound

HRID 1375958Notes

Reaction equation

HRID 1375958 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:37]=[CH:36][CH:35]=[CH:34][C:7]=1[C:8]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:22][CH2:21][N:20]([CH:23]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[C:24]([O:26]C)=[O:25])[CH2:19][CH2:18]2)=[CH:13][CH:12]=1)=[O:9].[OH-].[K+]>C(O)(C)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:37]=[CH:36][CH:35]=[CH:34][C:7]=1[C:8]([NH:10][C:11]1[CH:12]=[CH:13][C:14]([N:17]2[CH2:22][CH2:21][N:20]([CH:23]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:24]([OH:26])=[O:25])[CH2:19][CH2:18]2)=[CH:15][CH:16]=1)=[O:9]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 20773936HCID 20773936, compound

Product 1

HCID 22499392HCID 22499392, compoundYield 107.3%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of intermediate (30) (0.0006 mol) and potassium hydroxide (0.006 mol) in isopropanol (5 ml) was stirred at room temperature overnight. The solvent was evaporated. The residue was dissolved in isopropanol/HCl 6N and converted into the hydrochloric acid salt. The precipitate was filtered off and dried, yielding 0.31 g of 4-[4-[[2-(2-furanyl)benzoyl]amino]phenyl]-α-phenyl-1-piperazineacetic acid (intermediate 31).

Workup

  1. customThe solvent was evaporated
  2. dissolutionThe residue was dissolved in isopropanol/HCl 6N
  3. filtrationThe precipitate was filtered off
  4. customdried

Sources & evidence

ORD record
ord-73f8095899af4be3a1958b62646227fd
Source dataset
uspto-grants-2007_01
Patent number
US07169796B2

Reaction notes

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