Tetrahydrofuran → HCID 10405043, compound

HRID 1376115Notes

Reaction equation

HRID 1376115 reaction equation
[C:1]([O:5][C:6]([C:8]1[NH:9][C:10]2[C:15]([C:16]=1[NH:17][C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1)=[C:14]([F:24])[CH:13]=[CH:12][CH:11]=2)=[O:7])([CH3:4])([CH3:3])[CH3:2].O1CCC[CH2:26]1>CN(C)C=O>[C:1]([O:5][C:6]([C:8]1[N:9]([CH3:26])[C:10]2[C:15]([C:16]=1[NH:17][C:18]1[CH:19]=[CH:20][N:21]=[CH:22][CH:23]=1)=[C:14]([F:24])[CH:13]=[CH:12][CH:11]=2)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 9973705HCID 9973705, compound

Product 1

HCID 10405043HCID 10405043, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Follow the procedure of Example 24 but start with 4-fluoro-3-(4-pyridinylamino)-1H-indole-2-carboxylic tert-butyl ester, but substitute tetrahydrofuran for dimethylformamide to obtain the title compound: ESI/MS 342 (M+H); HPLC: Rt=1.41 min.

Sources & evidence

ORD record
ord-67c7f4a96ab94ec1a87ff8417b1c38cb
Source dataset
uspto-grants-2007_01
Patent number
US07169925B2

Reaction notes

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