Potassium Iodide → HCID 10859009, compound

HRID 1376177Notes

Reaction equation

HRID 1376177 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4]O.Cl[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=[C:9]([CH3:17])[CH:8]=1.[I-].[K+]>C(N(CC)CC)C>[CH3:17][C:9]1[CH:8]=[C:7]([NH:1][CH2:2][CH2:3][CH2:4][N:10]2[CH2:11][CH2:16][CH2:7][CH2:8][CH2:9]2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 90863-Amino-1-propanolHCID 779734-Chloro-2-methylquinoline

Product 1

HCID 10859009HCID 10859009, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Synthesis and purification were performed according to the procedure stated in example 152 using reagents 3-aminopropanol (15 mmol), 4-chloro-2-methylquinoline (15 mmol), 5 ml of triethylamine, and catalytic amounts of potassium iodide in the first step. The final product was purified by flash chromatography (eluent: ethyl acetate/triethylamine (95/5)). The solvent was removed under reduced pressure. The residue was crystallized with oxalic acid from diethyl ether/ethanol.

Workup

  1. customSynthesis and purification
  2. customThe final product was purified by flash chromatography (eluent: ethyl acetate/triethylamine (95/5))
  3. customThe solvent was removed under reduced pressure
  4. customThe residue was crystallized with oxalic acid from diethyl ether/ethanol

Sources & evidence

ORD record
ord-905dd5ffb19441fd9ae7951c477a430e
Source dataset
uspto-grants-2007_01
Patent number
US07169928B2

Reaction notes

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