Diethyl Oxalate → 4-(2-Hydroxyethyl)-2,3-morpholinedione

HRID 1376672Notes

Reaction equation

HRID 1376672 reaction equation
[C:1]([O:8][CH2:9][CH3:10])(=[O:7])[C:2]([O:4]CC)=O.[NH:11](CCO)[CH2:12][CH2:13][OH:14]>>[OH:14][CH2:13][CH2:12][N:11]1[CH2:10][CH2:9][O:8][C:1](=[O:7])[C:2]1=[O:4]

Participants

3

Reactant 2

HCID 7268Diethyl OxalateHCID 8113Diethanolamine

Product 1

HCID 4584884-(2-Hydroxyethyl)-2,3-morpholinedione

Procedure

In a flask similar to that used for example 9 was placed 146 g (1.0 mole) of diethyl oxalate, and to this flask was added dropwise 26 g (0.25 moles) of diethanolamine maintaining reaction temperature at 30° C. during 1 hour. After the dropping finished, the stirring was continued at 25° C. for further 2 hours and then crystals separated were taken by filtration to obtain N-hydroxyethylmorpholine-2,3-dione.

Workup

  1. customIn a flask similar to that used for example 9
  2. additionto this flask was added dropwise
  3. customcrystals separated
  4. filtrationwere taken by filtration

Sources & evidence

ORD record
ord-cad87176b6b1465597a6ef104b5a1933
Source dataset
uspto-grants-1997_09
Patent number
US05663262

Reaction notes

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