Hydrochloric Acid → HCID 22918809, compound

HRID 1376927Notes

Reaction equation

HRID 1376927 reaction equation
C([O:4][C:5]1[C:6]([CH3:19])=[C:7]([CH3:18])[C:8]([OH:17])=[C:9]([CH2:12][CH2:13][C:14]([CH3:16])=[CH2:15])[C:10]=1[CH3:11])(=O)C.[OH-].[K+].C(OCC)C.Cl>C(O)C.O>[OH:17][C:8]1[C:7]([CH3:18])=[C:6]([CH3:19])[C:5]([OH:4])=[C:10]([CH3:11])[C:9]=1[CH2:12][CH2:13][C:14]([CH3:16])=[CH2:15]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 14797Potassium HydroxideHCID 13680812HCID 13680812, compound

Product 1

HCID 22918809HCID 22918809, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent

Procedure

A solution containing 7.6 g (0.029 moles) of 4-(5-acetoxy-2-hydroxy-3,4,6-trimethylphenyl)-2-methyl-1-butene in 90 ml of 95% ethyl alcohol, is added with 90 ml of a solution containing 14.9 g (0.264 moles) of potassium hydroxide in 95% ethyl alcohol. The reaction mixture is kept for 22 hours at 90° C., then is diluted by adding ethyl ether and water, acidified to pH 5 with a 10% aqueous solution of hydrochloric acid and the product is extracted with ethyl ether. The crude product is obtained by evaporation of the solvent and used without further purification.

Workup

  1. additionis diluted
  2. extractionthe product is extracted with ethyl ether

Sources & evidence

ORD record
ord-497802db246e40f1838498e0cb0d36f7
Source dataset
uspto-grants-1997_09
Patent number
US05663389

Reaction notes

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