Hydrochloric Acid → HCID 86751213, compound

HRID 1377112Notes

Reaction equation

HRID 1377112 reaction equation
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:7][C:6]=1[Br:15])(=O)C.[ClH:16]>C(O)C>[ClH:16].[Br:15][C:6]1[CH:7]=[C:8]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:9]=[CH:10][C:5]=1[NH2:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 258026N-(2-bromo-4-tert-butylphenyl)acetamide

Product 1

HCID 86751213HCID 86751213, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 24.33 g (90 mmol) of N-acetyl-2-bromo-4-tert-butyl aniline in 73.5 ml of 95% ethanol and 46 ml of concentrated hydrochloric acid is heated under reflux one hour. Then the mixture is cooled and the product is filtered, washed with cold 95% ethanol and dried. The yield of title compound is 21.75 g (91%).

Workup

  1. temperatureunder reflux one hour
  2. temperatureThen the mixture is cooled
  3. filtrationthe product is filtered
  4. washwashed with cold 95% ethanol
  5. customdried

Sources & evidence

ORD record
ord-5875059ff93643f683c83cfc2abc72d8
Source dataset
uspto-grants-1997_09
Patent number
US05663448

Reaction notes

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