HCID 22913882, compound → HCID 22913582, compound

HRID 1377411Notes

Reaction equation

HRID 1377411 reaction equation
[CH2:1]([Mg]Br)[CH2:2][CH3:3].Cl[Si:7]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:12][CH2:11][CH:10]([CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[C:21]([F:23])[C:20]([O:24][CH:25]([F:27])[F:26])=[C:19]([F:28])[CH:18]=2)[CH2:9][CH2:8]1>C1COCC1>[F:28][C:19]1[CH:18]=[C:17]([CH2:16][CH2:15][CH2:14][CH2:13][CH:10]2[CH2:11][CH2:12][Si:7]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)([CH2:1][CH2:2][CH3:3])[CH2:8][CH2:9]2)[CH:22]=[C:21]([F:23])[C:20]=1[O:24][CH:25]([F:27])[F:26]

Participants

4

Reactant 2

HCID 22913882HCID 22913882, compoundHCID 178455851HCID 178455851, compound

Product 1

HCID 22913582HCID 22913582, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

50 ml (0.13 mols) of a THF solution of 2.5M of propylmagnesium bromide was dropped in a mixed solution of 44.5 g (0.1 mol) of 1-chloro-1-phenyl-4-(4-(3,5-difluoro-4-difluoromethoxyphenyl)butyl)-1-silacyclohexane and 300 ml of THF. After ordinary after-treatments, 4-(4-(3,5-difluoro-4-difluoromethoxyphenyl)butyl)-1-phenyl-1-propyl-1-silacyclohexane was obtained.

Sources & evidence

ORD record
ord-1786171af10b4aaf8e98a2eabf15a4ec
Source dataset
uspto-grants-1997_09
Patent number
US05665271

Reaction notes

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