Hydrochloric Acid → HCID 178441667, compound

HRID 1377520Notes

Reaction equation

HRID 1377520 reaction equation
[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]3[N:27](C(OCC)C)[N:26]=[N:25][N:24]=3)=[CH:13][CH:12]=2)[C:8]([CH:33]([C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([CH2:41][N:42]([CH2:45][CH3:46])[CH2:43][CH3:44])[N:36]=2)[OH:34])=[C:7]([Cl:47])[N:6]=1)[CH2:2][CH2:3][CH3:4].Cl.[OH-].[Na+]>O1CCCC1>[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]3[NH:27][N:26]=[N:25][N:24]=3)=[CH:13][CH:12]=2)[C:8]([CH:33]([C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([CH2:41][N:42]([CH2:43][CH3:44])[CH2:45][CH3:46])[N:36]=2)[OH:34])=[C:7]([Cl:47])[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22914863HCID 22914863, compound

Product 1

HCID 178441667HCID 178441667, compoundYield 77.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

49.7 mg (0.076 mmole) of the compound obtained in step 1 was dissolved in 1 ml of tetrahydrofuran and to the resulting solution was added 0.5 ml of aqueous 1N HCl solution. The resultant was stirred for 8 hours at room temperature, neutralized with aqueous 1N NaOH solution, concentrated under reduced pressure and purified with silica gel column chromatography to obtain 34.4 mg of the title compound (yield 77%).

Workup

  1. concentrationconcentrated under reduced pressure
  2. custompurified with silica gel column chromatography

Sources & evidence

ORD record
ord-dcdfc5a2b44a49b29e46408da1d37c88
Source dataset
uspto-grants-1997_09
Patent number
US05665738

Reaction notes

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