反应详情

1-(1-Boc-4-piperidyl)-4-phenyl-3,1-benzoxazin-2-one from Step 3 above (1.97 g, 4.67 mmol) was stirred in ethyl acetate in an ice bath, then saturated with HCl gas and stirred another 15 min in the cold. The mixture was evaporated in vacuo. Three portions of ethyl acetate were successively added and evaporated in vacuo to give 1-(4-piperidyl)-4-phenyl-3,1-benzoxazin-2-one hydrochloride.

1. customThe mixture was evaporated in vacuo
2. additionThree portions of ethyl acetate were successively added
3. customevaporated in vacuo