Hydrochloric Acid → 1-(4-Piperidyl)-4-phenyl-3,1-benzoxazin-2-one hydrochloride

HRID 1377699Notes

Reaction equation

HRID 1377699 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:16][C:15]2=[O:30])[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[ClH:31]>C(OCC)(=O)C>[ClH:31].[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:16][C:15]2=[O:30])[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 229146691-(1-Boc-4-piperidyl)-4-phenyl-3,1-benzoxazin-2-one

Product 1

HCID 229146511-(4-Piperidyl)-4-phenyl-3,1-benzoxazin-2-one hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-(1-Boc-4-piperidyl)-4-phenyl-3,1-benzoxazin-2-one from Step 3 above (1.97 g, 4.67 mmol) was stirred in ethyl acetate in an ice bath, then saturated with HCl gas and stirred another 15 min in the cold. The mixture was evaporated in vacuo. Three portions of ethyl acetate were successively added and evaporated in vacuo to give 1-(4-piperidyl)-4-phenyl-3,1-benzoxazin-2-one hydrochloride.

Workup

  1. customThe mixture was evaporated in vacuo
  2. additionThree portions of ethyl acetate were successively added
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-eb8260ad76524aa1bda9759519b12f2c
Source dataset
uspto-grants-1997_09
Patent number
US05665719

Reaction notes

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