Hydrochloric Acid → 1-(4-Piperidyl)-4-methyl-3,1-benzoxazin-2-one hydrochloride

HRID 1377703Notes

Reaction equation

HRID 1377703 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH:17]([CH3:24])[O:16][C:15]2=[O:25])[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[ClH:26]>C(OCC)(=O)C>[ClH:26].[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH:17]([CH3:24])[O:16][C:15]2=[O:25])[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 229147301-(1-Boc-4-piperidyl)-4-methyl-3,1-benzoxazin-2-one

Product 1

HCID 226446811-(4-Piperidyl)-4-methyl-3,1-benzoxazin-2-one hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-(1-Boc-4-piperidyl)-4-methyl-3,1-benzoxazin-2-one from Step 3 above (1.98 g, 5.72 mmol) was stirred in ethyl acetate in an ice bath, then saturated with HCl gas and stirred another 15 min in the cold. The mixture was evaporated in vacuo. Three portions of ethyl acetate were successively added and evaporated in vacuo to give 1-(4-piperidyl)-4-methyl-3,1-benzoxazin-2-one hydrochloride.

Workup

  1. customThe mixture was evaporated in vacuo
  2. additionThree portions of ethyl acetate were successively added
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-1f898051891147c5b189261c4b762556
Source dataset
uspto-grants-1997_09
Patent number
US05665719

Reaction notes

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