Hydrochloric Acid → HCID 22914642, compound

HRID 1377706Notes

Reaction equation

HRID 1377706 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH2:17][O:16][C:15]2=[O:24])[CH:10]([C:25]([O:27][CH3:28])=[O:26])[CH2:9]1)(OC(C)(C)C)=O.[ClH:29]>C(OCC)(=O)C>[ClH:29].[N:14]1([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH:10]2[C:25]([O:27][CH3:28])=[O:26])[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[CH2:17][O:16][C:15]1=[O:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22914677HCID 22914677, compound

Product 1

HCID 22914642HCID 22914642, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Methyl 1-Boc-4-(3,1-benzoxazin-2-one-1-yl)-3-piperidine carboxylate from Step 3 above (0.6 g, 1.5 mmol) was stirred in ethyl acetate in an ice bath, then saturated with HCl gas and stirred another 15 min in the cold. The mixture was evaporated in vacuo. Three portions of ethyl acetate were successively added and evaporated in vacuo to give methyl 4-(3,1-benzoxazin-2-one-1-yl)-3-piperidine carboxylate hydrochloride.

Workup

  1. customThe mixture was evaporated in vacuo
  2. additionThree portions of ethyl acetate were successively added
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-2037993e2b94493c881bd5879e6287c4
Source dataset
uspto-grants-1997_09
Patent number
US05665719

Reaction notes

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