2-Aminonicotinic acid → (2-Aminopyridin-3-yl)methanol

HRID 1377729Notes

Reaction equation

HRID 1377729 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[NH2:1][C:2]1[C:3]([CH2:4][OH:5])=[CH:7][CH:8]=[CH:9][N:10]=1

Participants

4

Reactant 2

HCID 729302-Aminonicotinic acidHCID 21226445Aluminium lithium hydride

Product 1

HCID 11159325(2-Aminopyridin-3-yl)methanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The methyl ester of 2-amino nicotinic acid is reduced with lithium aluminium hydride in a solvent such as THF to give 2-amino-3-hydroxymethylpyridine.

Sources & evidence

ORD record
ord-a60b71f25bd048a5b3e9fdab000ee1cd
Source dataset
uspto-grants-1997_09
Patent number
US05665719

Reaction notes

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