Triethylsilane → HCID 53648849, compound

HRID 1377860Notes

Reaction equation

HRID 1377860 reaction equation
[CH3:1][O:2][C:3](=[O:25])[C:4]1[C:9]([CH:10]=O)=[C:8]([O:12][Si:13]([CH3:21])([CH3:20])[C:14]([CH3:19])([CH3:18])[CH:15]([CH3:17])[CH3:16])[CH:7]=[C:6]([O:22][CH3:23])[C:5]=1[F:24].C([SiH](CC)CC)C>FC(F)(F)C(O)=O.ClCCl>[CH3:1][O:2][C:3](=[O:25])[C:4]1[C:9]([CH3:10])=[C:8]([O:12][Si:13]([CH3:20])([CH3:21])[C:14]([CH3:19])([CH3:18])[CH:15]([CH3:16])[CH3:17])[CH:7]=[C:6]([O:22][CH3:23])[C:5]=1[F:24]

Participants

5

Reactant 2

HCID 12052TriethylsilaneHCID 53833163HCID 53833163, compound

Product 1

HCID 53648849HCID 53648849, compoundYield 87.9%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

1H-NMR (250 MHz, CDCl3): δ 0.18 (s, 6H); 0.80 (d, 6H); 0.85 (s, 6H); 1.60 (m, 1H); 3.78 (s, 3H); 3.83 (s, 3H); 6.29 (d, 1H); 10.07 (d, 1H) ppm. (b) To a solution of 1.3 g of 2-fluoro-6-formyl-3-methoxy-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzoic acid methyl ester in 4 ml of trifluoroacetic acid, cooled to 0° C., was added over 10 min a solution of 0.6 g of triethylsilane in 4 ml of dichloromethane. The solution was kept at 0° C. for 18 h and then evaporated in vacuo. The residue was taken up in ethyl acetate and the solution was successively washed with water, saturated sodium carbonate solution and brine, and dried over sodium sulfate. The solvent was evaporated in vacuo and the residue was chromatographed on silica gel using ethyl acetate/hexane (1:3, v/v) as eluent to yield 1.1 g of 2-fluoro-3-methoxy-6-methyl-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzoic acid methyl ester as colorless oil.

Workup

  1. customevaporated in vacuo
  2. washthe solution was successively washed with water, saturated sodium carbonate solution and brine
  3. dry with materialdried over sodium sulfate
  4. customThe solvent was evaporated in vacuo
  5. customthe residue was chromatographed on silica gel

Sources & evidence

ORD record
ord-ae6108b723924582a16fdf789d246882
Source dataset
uspto-grants-1997_09
Patent number
US05665746

Reaction notes

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