反应详情

To 750 ml of 12% strength hydrogen peroxide, heated to 80° C., there were added in portions 101 g (0.5 mol) of 4-hydroxy-2-mercapto-5-methoxy-6-methoxymethylpyrimidine in such a way that a temperature of 80° C. was maintained. Stirring was then continued for 2 hours at 80° C. After cooling, solid sodium disulfite was added until potassium iodide/starch paper no longer showed a reaction with peroxide, and the mixture was then neutralized by adding potassium carbonate. The water was distilled off, and the solid residue, to which a little ethanol had been added, was then suspended in methylene chloride and subjected to filtration with suction. After concentration of the filtrate, 63 g (70% of theory) of product of melting point 141°-143° C. were obtained.

1. temperaturewas maintained
2. temperatureAfter cooling
3. distillationThe water was distilled off
4. additionthe solid residue, to which a little ethanol had been added
5. filtrationsubjected to filtration with suction
6. customAfter concentration of the filtrate, 63 g (70% of theory) of product of melting point 141°-143° C. were obtained