Benzoyl chloride → 4-Benzoyl-1,2,3,4-tetrahydroquinoxalin-2-one

HRID 1378749Notes

Reaction equation

HRID 1378749 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[C:6](C)(C)[NH:5]2.C(N(CC)CC)C.[C:22](Cl)(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C1COCC1>[C:22]([N:5]1[C:4]2[C:9](=[CH:10][CH:11]=[CH:2][CH:3]=2)[NH:8][C:7](=[O:12])[CH2:6]1)(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 229128926-Fluoro-3,3-dimethyl-3,4-dihydro-1H-quinoxalin-2-one

Product 1

HCID 7343784-Benzoyl-1,2,3,4-tetrahydroquinoxalin-2-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1,2,3,4-tetrahydroquinoxalin-2-one (IV, EXAMPLE 1, 0.593 g) and triethylamine (0.725 ml) in THF (5 ml) is cooled at 0°. To this is added benzoyl chloride (0.56 ml). After the addition is complete, the ice bath is removed and additional THF (5 ml) is added. The reaction is stirred for 30 min and then partitioned between ethyl acetate, aq. sodium bicarbonate, and saline. The organic phases are separated and the organic phase is dried over magnesium sulfate and concentrated. The crude product is recrystallized from methanol/dichloromethane/hexane to give the title compound, mp 208.0°-208.5°; MS (m/z) at 252; IR (mineral oil) 1684, 1666, 1502, 757 and 1362 cm-1 ; NMR (CDCl3) 4.58, 6.7, 6.79, 6.98, 7.10, 7.34 and 7.40 δ.

Workup

  1. temperatureis cooled at 0°
  2. additionAfter the addition
  3. customthe ice bath is removed
  4. additionadditional THF (5 ml) is added
  5. custompartitioned between ethyl acetate, aq. sodium bicarbonate, and saline
  6. customThe organic phases are separated
  7. dry with materialthe organic phase is dried over magnesium sulfate
  8. concentrationconcentrated
  9. customThe crude product is recrystallized from methanol/dichloromethane/hexane

Sources & evidence

ORD record
ord-f10170f8bcb84163ae961c9a5f7c1cd9
Source dataset
uspto-grants-1997_09
Patent number
US05668282

Reaction notes

Loading…