4-Bromophenol → p-Bromo-(1-methoxyethoxy)benzene

HRID 1378893Notes

Reaction equation

[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([Br:8])[CH:2]=1.[CH:9]([O:11][CH3:12])=[CH2:10]>>[Br:8][C:3]1[CH:4]=[CH:5][C:6]([O:7][CH:9]([O:11][CH3:12])[CH3:10])=[CH:1][CH:2]=1

Participants

Reactant 2

HCID 78084-Bromophenol

HCID 7861Methyl vinyl ether

Product 1

HCID 22908633p-Bromo-(1-methoxyethoxy)benzeneYield 90%

Procedure

Using p-bromophenol (17.3 g, 0.1 mole) and methyl vinyl ether (14.0 g, 0.2 mole), the reaction was carried out in the same manner as described in Synthesis Example 1, (1), and the crude oil (24 g) was purified by distillation under reduced pressure to afford 20.8 g of p-bromo-(1-methoxyethoxy)benzene as a pale yellow oil having a boiling point 89°-90° C./2 mmHg.

Workup

customas described in Synthesis Example 1, (1),
distillationthe crude oil (24 g) was purified by distillation under reduced pressure

Sources & evidence

ORD record: ord-4dfa19ee82e848c59c9ac7d1d2957e9e
Source dataset: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05670299

Reaction notes

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