3-(3-Pyridinyl)-2-propenoic acid → 3-(Pyridin-3-yl)propanoic acid

HRID 1379401Notes

Reaction equation

HRID 1379401 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:9]([OH:11])=[O:10])[CH:2]=1.[H][H]>[Pd].C(OCC)(=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH:2]=1

Participants

5

Reactant 2

HCID 1019843-(3-Pyridinyl)-2-propenoic acidHCID 178418361HCID 178418361, compound

Product 1

HCID 2596243-(Pyridin-3-yl)propanoic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 3 g (20 mmol) of 3-(3-pyridinyl)acrylic acid and 0.3 g of 10% palladium on carbon in 150 ml of ethyl acetate was shaken under 4 atmospheres of hydrogen for 24 h. After filtration, the resulting solution was concentrated in vacuo to provide the desired compound.

Workup

  1. filtrationAfter filtration
  2. concentrationthe resulting solution was concentrated in vacuo

Sources & evidence

ORD record
ord-7c03a54e9a2441a88373bad2400446a1
Source dataset
uspto-grants-1997_09
Patent number
US05670675

Reaction notes

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