反应详情

温度

40 °C

Combine 2-nitromethylene-thiazolidine (10.0 g) and isopropanol (40 mL). Add methylamine (14.7 g). Heat to 40° C. After 5 minutes, add 5-[(dimethylamino)methyl]-2-(chloromethyl)-furan hydrochloride (13.05 g) portionwise over 1.5 hours. After 3 hours, cool to ambient temperature. Add aqueous sodium hydroxide solution (11.6 g, 50% by weight) and water (20 g). Extract repeatedly with methyl isobutyl ketone. Combine the organic layers and evaporate in vacuo to give the title compound.

1. waitAfter 3 hours
2. temperaturecool to ambient temperature
3. extractionExtract repeatedly with methyl isobutyl ketone
4. customevaporate in vacuo