反应详情

5-(2-Methyl-1,3-dioxolan-2yl)-3-phenyl-2,1-benzisoxazole (1.50 g, 5.3 m mol), triethyl amine (0.3 ml) and 5% palladium on carbon (0.15 g) were combined in dry tetrahydrofuran (13 ml). The apparatus wa flushed with nitrogen and then hydrogen. A static hydrogen atmosphere was maintained (1 atm.) and the progress of the reaction followed by gas chromatography. The starting material and product have retention times of 11.15 and 11.33 min. respectively. When conversion was complete, the mixture was filtered through a pad of Celite to yield a clear yellow solution. Evaporation of the solution yielded a yellow solid (1.35 g) of mp. 108°-111° C.

1. customThe apparatus wa flushed with nitrogen
2. temperatureA static hydrogen atmosphere was maintained (1 atm.)
3. customretention times of 11.15 and 11.33 min.
4. filtrationthe mixture was filtered through a pad of Celite
5. customto yield a clear yellow solution
6. customEvaporation of the solution