Sulfuric Acid → 1,3-Benzoxazol-7-ol

HRID 1380079노트

반응식

HRID 1380079 반응식
[OH:1][C:2]1[C:8]([OH:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[CH2:10](OC(OCC)OCC)C.S(=O)(=O)(O)O>>[OH:9][C:8]1[C:2]2[O:1][CH:10]=[N:4][C:3]=2[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 31214Ethyl orthoformateHCID 189460Catecholamine

생성물 1

HCID 202421161,3-Benzoxazol-7-ol

실험 절차

A mixture of 2,3-dihydroxyaniline (2.5 g.), triethylorthoformate (4.5 g.) and 0.1 g. sulfuric acid is heated at 130° C. for one hour. After cooling, the remaining material is purified by HPLC on silica gel.

후처리

  1. temperatureAfter cooling
  2. customthe remaining material is purified by HPLC on silica gel

출처 및 근거

ORD 기록
ord-7720a76b41924fb2be5a4377869cf05b
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04579865

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