反应详情

温度

0 °C

Dissolve 16.0 g (0.019 mole) of 2,4,5-trimethyl-1H-imidazole hydrochloride in 125 ml dry N,N-dimethylformamide and cool to 0° C. Add 8.75 g (0.218 mole) of sodium hydride (60%), stir at 0° C. for 30 minutes and then heat reaction mixture to 100° C. for one hour. Cool to 0° C. and then add 18.0 ml (0.114 mole) of n-heptyl bromide to reaction mixture. Upon completion of addition, heat to 100° C. for four hours, following the progress of the reaction by thin-layer chromatography on silica gel (methanol:1M sodium chloride, 95:5). At the completion of the reaction, cool to room temperature and add 2 ml water. Filter precipitated salts and evaporate solvent.

1. temperatureheat
2. customreaction mixture to 100° C. for one hour
3. temperatureCool to 0° C.
4. customto reaction mixture
5. additionUpon completion of addition
6. temperatureheat to 100° C. for four hours
7. customthe progress of the reaction by thin-layer chromatography on silica gel (methanol:1M sodium chloride, 95:5)
8. customAt the completion of the reaction
9. temperaturecool to room temperature
10. filtrationFilter
11. customprecipitated salts
12. customevaporate solvent