Phosphorus oxychloride → HCID 23319695, compound

HRID 1380394Notes

Reaction equation

[Cl:1][C:2]1[C:7]2=[C:8]([CH:12]=O)[S:9][C:10]([CH3:11])=[C:6]2[N:5]=[C:4]([CH3:14])[CH:3]=1.Cl.[NH2:16]O.P(Cl)(Cl)(Cl)=O>>[Cl:1][C:2]1[C:7]2[C:6](=[C:10]([CH3:11])[S:9][C:8]=2[C:12]#[N:16])[N:5]=[C:4]([CH3:14])[CH:3]=1

Participants

Reactant 3

HCID 24813Phosphorus oxychloride

HCID 443297Hydroxyamine hydrochloride

HCID 23319701HCID 23319701, compound

Product 1

HCID 23319695HCID 23319695, compound

Procedure

4-Chloro-2,7-dimethylthieno[3,4-]pyridine-5-carboxaldehyde is reacted with hydroxylamine hydrochloride and phosphoryl chloride by standard procedures to give 4-chloro-2,7-dimethylthieno[3,4-b]pyridine-5-carbonitrile.

Sources & evidence

ORD record: ord-eb058b1c4564422ca87d9112c476edc7
Source dataset: uspto-grants-1986_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04581455

Reaction notes

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