Ethanolamine → HCID 21281528, compound

HRID 1380462Notes

Reaction equation

HRID 1380462 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].Cl[C:6]([O:8][CH2:9][CH:10]([CH3:12])[CH3:11])=[O:7]>C(Cl)Cl>[OH:2][CH2:1][CH2:3][NH:4][C:6](=[O:7])[O:8][CH2:9][CH:10]([CH3:12])[CH3:11]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 62365Isobutyl chloroformate

Product 1

HCID 21281528HCID 21281528, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

42.8 g of ethanolamine are placed in 350 ml of methylene chloride. 47.8 g of isobutyl chloroformate are then added dropwise during 1 hour at 5°-15° C. while cooling with ice. After stirring at room temperature for a further 4 hours, the methylene chloride is removed by evaporation and the residue is distilled. There is obtained pure isobutyl 2-hydroxyethylcarbamate; b.p. 111°-113° C./0.07 Torr.

Workup

  1. temperaturewhile cooling with ice
  2. customthe methylene chloride is removed by evaporation
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-cfe95c309107459085a1f8fdc4504090
Source dataset
uspto-grants-1986_04
Patent number
US04582526

Reaction notes

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