Water → HCID 18755078, compound

HRID 1380601Notes

Reaction equation

HRID 1380601 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:18])[C:9]([CH3:17])([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH3:10])=[CH:4][CH:3]=1.[SH:19][CH:20](O)C.[C:23](=[O:26])([O-])[O-].[K+].[K+].O>CN(C)C=O.CCOCC>[OH:26][CH2:23][CH2:20][S:19][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:18])[C:9]([CH3:17])([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH3:10])=[CH:4][CH:3]=1

Participants

7

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 4713212Mercapto-ethanolHCID 157024081-(4-Chlorophenyl)-2-methyl-2-(morpholin-4-yl)propan-1-one

Product 1

HCID 18755078HCID 18755078, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
95 °C

Procedure

20.1 g (0.075 mol) of 1-(4-chlorophenyl)-2-methyl-2-morpholinopropan-1-one and 6.45 g (0.0825 mol) of mercaptoethanol in 100 ml of dimethylformamide are warmed to 95° C. 20.7 g (0.15 mol) of anhydrous potassium carbonate are then added. The suspension is stirred at 95° C. until the starting compound can no longer be detected. The reaction mixture is cooled and water is poured over it, and the product is taken up in ether. The ether layer is washed with water, dried over Na2SO4 and concentrated. The resulting oil is purified over a drying column, and crystallises after a little time.

Workup

  1. temperatureThe reaction mixture is cooled
  2. washThe ether layer is washed with water
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated
  5. customThe resulting oil is purified over a drying column
  6. customcrystallises after a little time

Sources & evidence

ORD record
ord-80adfedaaf734f93b5f5f5f0e8406561
Source dataset
uspto-grants-1986_04
Patent number
US04582862

Reaction notes

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