Benzyl Bromide → HCID 53799587, compound

HRID 1380659Notes

Reaction equation

HRID 1380659 reaction equation
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[C:5]([CH2:11][C:12]([OH:14])=[O:13])[CH:6]=[CH:7][CH:8]=2)[NH:3]1.[OH-].[Na+].[CH2:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>O.[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[C:18]1([CH2:17][O:13][C:12](=[O:14])[CH2:11][C:5]2[CH:6]=[CH:7][CH:8]=[C:9]3[C:4]=2[NH:3][C:2](=[O:1])[CH2:10]3)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

7

Reactant 3

HCID 7498Benzyl BromideHCID 14798Sodium HydroxideHCID 13603775HCID 13603775, compound

Product 1

HCID 53799587HCID 53799587, compound

Reagents, catalysts & solvents 3

HCID 74236Tetrabutylammonium BromideCatalystHCID 962WaterSolventHCID 1140TolueneSolvent

Procedure

A solution of 20.5 g of 2,3-dihydro-2-oxo-1H-indole-7-acetic acid (0.1 mole) and 4.0 g (0.1 mole) of sodium hydroxide in 200 ml of water is vigorously stirred together with a solution of 20.5 g (0.12 mole) of benzyl bromide and 3.4 g (0.1 mole) of tetrabutylammonium bromide in 300 ml of toluene.

Sources & evidence

ORD record
ord-345ad44a07fb4506a0a6f14c80dfd05b
Source dataset
uspto-grants-1986_04
Patent number
US04582909

Reaction notes

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