3-(3-Chloropropyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one → 1-[7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(8-methoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-propane

HRID 1380888Notes

Reaction equation

HRID 1380888 reaction equation
[CH3:1][O:2][C:3]1[C:18]([O:19][CH3:20])=[CH:17][C:6]2[CH2:7][C:8](=[O:16])[N:9]([CH2:12][CH2:13][CH2:14]Cl)[CH2:10][CH2:11][C:5]=2[CH:4]=1.[CH3:21][O:22][C:23]1[CH:24]=[CH:25][CH:26]=[C:27]2[C:32]=1[CH2:31][CH:30]([NH:33][CH3:34])[CH2:29][CH2:28]2>C(N(CC)CC)C>[CH3:1][O:2][C:3]1[C:18]([O:19][CH3:20])=[CH:17][C:6]2[CH2:7][C:8](=[O:16])[N:9]([CH2:12][CH2:13][CH2:14][N:33]([CH3:34])[CH:30]3[CH2:29][CH2:28][C:27]4[C:32](=[C:23]([O:22][CH3:21])[CH:24]=[CH:25][CH:26]=4)[CH2:31]3)[CH2:10][CH2:11][C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 130925103-(3-Chloropropyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-oneHCID 135796478-Methoxy-2-methylamino-1,2,3,4-tetrahydronaphthalene

Product 1

HCID 135796551-[7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(8-methoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-propane

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound is prepared analogously to Example 1 by reacting 1-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-3-chloropropane, triethylamine and 8-methoxy-2-methylamino-1,2,3,4-tetrahydronaphthalene. Mp: 141°-143° C. (decomp.).

Sources & evidence

ORD record
ord-ff4b78003f1a430899b06b3d68803ffb
Source dataset
uspto-grants-1986_04
Patent number
US04584293

Reaction notes

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