反应详情

A mixture of 300 g of 4-trifluoromethylcinnamic acid ethyl ester, 500 g of nitromethane, and 39 g of tetramethylguanidine is allowed to stir for 72 hours. The solution is diluted with diethyl ether and aqueous hydrochloric acid solution (1 N, 1 liter) is added. The organic layer is separated, dried over anhydrous magnesium sulfate and evaporated to give 4-nitro-3-(4-trifluoromethylphenyl)butanoic acid ethyl ester.

1. additionis added
2. customThe organic layer is separated
3. dry with materialdried over anhydrous magnesium sulfate
4. customevaporated