Hydrochloric Acid → 1-(3-Diethylaminopropyl)-3-(3-diethylaminopropylamino)indazole dihydrochloride

HRID 1381312Notes

Reaction equation

HRID 1381312 reaction equation
[CH2:1]([N:3]([CH2:25][CH3:26])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([NH:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])=[N:8]1)[CH3:2].[ClH:27].C(OCC)C>C(O)C>[ClH:27].[ClH:27].[CH2:25]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([NH:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:21][CH3:22])[CH2:23][CH3:24])=[N:8]1)[CH3:26]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 30308371-(3-Diethylaminopropyl)-3-(3-diethylaminopropylamino)indazole

Product 1

HCID 233240621-(3-Diethylaminopropyl)-3-(3-diethylaminopropylamino)indazole dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 3.0 g of 1-(3-diethylaminopropyl)-3-(3-diethylaminopropylamino)indazole and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Anhydrous diethyl ether was added to the solution to separate crystals. Then the crystals were obtained by filtration and dried to give 1-(3-diethylaminopropyl)-3-(3-diethylaminopropylamino)indazole dihydrochloride.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThen the crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-b0e8d20b743f4702b81cc05b46a44456
Source dataset
uspto-grants-1986_04
Patent number
US04585869

Reaction notes

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