Styrene Oxide → HCID 13210715, compound

HRID 1381524Notes

Reaction equation

HRID 1381524 reaction equation
[CH2:1]1[O:9][CH:2]1[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:10][O:11][CH2:12][CH2:13][NH2:14]>>[CH3:10][O:11][CH2:12][CH2:13][NH:14][CH2:1][CH:2]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:9]

Participants

3

Reactant 2

HCID 7276Styrene OxideHCID 80182-Methoxyethylamine

Product 1

HCID 13210715HCID 13210715, compoundYield 39%

Procedure

A mixture of styrene oxide (2.40 g 0.030 mole) and 2-methoxyethylamine (4.50 g, 0.060mole) was heated on a steam bath for 16 hours. After cooling to ambient temperature the oil began to crystallize. Trituration in isooctane followed by filtration gave a slightly impure solid. Recrystallization from isopropyl ether gave 1.52 g (39%) of the product, mp 77°-80° C.

Workup

  1. temperaturewas heated on a steam bath for 16 hours
  2. customto crystallize
  3. filtrationTrituration in isooctane followed by filtration
  4. customgave a slightly impure solid
  5. customRecrystallization from isopropyl ether

Sources & evidence

ORD record
ord-38964c5ba2344464ad9ccd17578732b1
Source dataset
uspto-grants-1989_02
Patent number
US04803200

Reaction notes

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