Sodium Bicarbonate → HCID 178515951, compound

HRID 1381544Notes

Reaction equation

HRID 1381544 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]1[CH:14]=[CH:13][NH:12][N:11]=1.C(=O)(O)[O-].[Na+]>Br>[NH:12]1[CH:13]=[CH:14][C:10]([NH:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[OH:2])=[N:11]1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 178489578HCID 178489578, compound

Product 1

HCID 178515951HCID 178515951, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

The product of step (b) (4.6 g) was dissolved in 48% aqueous HBr (100 ml) and refluxed for 8 hours. The mixture was poured onto water (750 ml), neutralised with solid sodium bicarbonate, extracted with ethyl acetate, washed with brine and evaporated to give the title compound as a white crystalline solid, 0.49 g, mp 163°-4° (from ethyl acetate/cyclohexane).

Workup

  1. temperaturerefluxed for 8 hours
  2. additionThe mixture was poured onto water (750 ml)
  3. extractionextracted with ethyl acetate
  4. washwashed with brine
  5. customevaporated

Sources & evidence

ORD record
ord-8a642681a8dc47b3a587b47fa7d6538b
Source dataset
uspto-grants-1989_02
Patent number
US04803216

Reaction notes

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