Hydrochloric Acid → HCID 14838488, compound

HRID 1381546Notes

Reaction equation

HRID 1381546 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]1[CH:14]=[CH:13][N:12]([CH3:15])[N:11]=1.C(=O)(O)[O-].[Na+].[ClH:21]>ClCCl>[ClH:21].[CH3:15][N:12]1[CH:13]=[CH:14][C:10]([NH:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[OH:2])=[N:11]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 14838486HCID 14838486, compound

Product 1

HCID 14838488HCID 14838488, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

The pyrazole from step (a) (1.7 g) was dissolved in dichloromethane (30 ml) under an atmosphere of nitrogen. Brown tribromide (8 ml) in dichloromethane was added dropwise and the mixture stirred at room temperature for 24 hours. After addition of dilute sodium bicarbonate, the organic phase was removed, dried and evaporated to give a pale oil, which was converted to the hydrochloride salt of the title compound, by trituration with ethereal HCl, to give an off-white solid, 0.75 g, mp 162°-164°.

Workup

  1. customthe organic phase was removed
  2. customdried
  3. customevaporated
  4. customto give a pale oil, which

Sources & evidence

ORD record
ord-2fc4b1a7ce2645cfa82921faf02625ab
Source dataset
uspto-grants-1989_02
Patent number
US04803216

Reaction notes

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