Acetyl chloride → HCID 21276499, compound

HRID 1381685Notes

Reaction equation

HRID 1381685 reaction equation
[OH:1][CH2:2][CH:3]1[C:8](=[O:9])[CH2:7][CH2:6][S:5][CH2:4]1.C(N(CC)CC)C.[C:17](Cl)(=[O:19])[CH3:18]>C(Cl)Cl>[C:17]([O:1][CH2:2][CH:3]1[C:8](=[O:9])[CH2:7][CH2:6][S:5][CH2:4]1)(=[O:19])[CH3:18]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 11804905HCID 11804905, compound

Product 1

HCID 21276499HCID 21276499, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To an ice-cooled solution of 1.26 g (0.0086 mol) of product from Step C and 1.44 g (0.0142 mol) of triethylamine in 25 ml of methylene chloride was added dropwise 0.75 g (0.0095 mol) of acetyl chloride. The solution was stirred for four hours at 0° C., after which time it was washed with water, a saturated solution of sodium bicarbonate, and water. The organic phase was dried (MgSO4), filtered, and evaporated to give 1.52 g (94%) of product.

Workup

  1. washafter which time it was washed with water
  2. dry with materialThe organic phase was dried (MgSO4)
  3. filtrationfiltered
  4. customevaporated

Sources & evidence

ORD record
ord-7998e6bddfaa4b2c822fb428ef61ea9e
Source dataset
uspto-grants-1989_02
Patent number
US04803286

Reaction notes

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