Water → HCID 21276535, compound

HRID 1381718Notes

Reaction equation

HRID 1381718 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:14](=[O:39])[CH:15]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])C(OC(C)(C)C)=O)[CH:5]=[CH:6][C:7]=1[C:8]([O:10][CH:11]([CH3:13])[CH3:12])=[O:9].FC(F)(F)C(O)=O.O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([C:14](=[O:39])[CH2:15][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[CH:5]=[CH:6][C:7]=1[C:8]([O:10][CH:11]([CH3:13])[CH3:12])=[O:9]

Participants

5

Reactant 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 14372232HCID 14372232, compound

Product 1

HCID 21276535HCID 21276535, compoundYield 97.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

335 mg of product from Example 9 was dissolved in 10 ml of methylene chloride and 10 ml of trifluroacetic acid was added. The reaction mixture was stirred at room temperature for 1.5 hours and added to 20 ml of water. The organic layer was separated and dried over sodium sulfate. The solvent was removed using a rotary evaporator to give 270 mg of the titled product.

Workup

  1. customThe organic layer was separated
  2. dry with materialdried over sodium sulfate
  3. customThe solvent was removed
  4. customa rotary evaporator

Sources & evidence

ORD record
ord-6a9cf7a3fca64adca9b38a7cad76c1fc
Source dataset
uspto-grants-1989_02
Patent number
US04803294

Reaction notes

Loading…