反应详情

Anthracene-1-carboxylic acid (15B, 24g, 0.108 mol) was treated with N-chlorosuccinimide (Aldrich, 24 g, 0.18 mol) in N-methylpyrrolidinone (Eastman, 600 mL) and heated under N2 at 90° for 1.5 h. The reaction mixture was diluted with H2O (3.5 L), filtered, dried, and the precipitate recrystallized from EtOAc to afford 16.41 g (59%) of 10-chloroanthracene-1-carboxylic acid mp 275°-277°, (C, H, Cl).

1. temperatureheated under N2 at 90° for 1.5 h
2. filtrationfiltered
3. customdried
4. customthe precipitate recrystallized from EtOAc