Sodium Carbonate → HCID 10751498, compound

HRID 1381903Notes

Reaction equation

HRID 1381903 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.C[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[C:18](=O)([O-])[O-].[Na+].[Na+]>O>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:12]2[CH2:17][CH2:16][NH:15][CH:14]([CH3:18])[CH2:13]2)=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 531671-MethylpiperazineHCID 678794-Fluorobenzoyl chloride

Product 1

HCID 10751498HCID 10751498, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Add 25.0g (0.158 mol) of p-fluorobenzoyl chloride drop-wise to a 0° C. solution of 15.0 g (0.150 mol) of N-methylpiperazine and 20.0 g (0.189 mol) of sodium carbonate in 100 mL of water. Stir the resultant solution at 0° C. for about 30 minutes, then at room temperature for about 2 hr. Extract the resultant solution with methylene chloride (2×100 mL). Dry the combined extracts with Na2SO4 and evaporate the solvent to give the title compound.

Workup

  1. extractionExtract the resultant solution with methylene chloride (2×100 mL)
  2. dry with materialDry the combined extracts with Na2SO4
  3. customevaporate the solvent

Sources & evidence

ORD record
ord-7ab1e909f8e04f358266d4fbc20b9ac9
Source dataset
uspto-grants-1989_02
Patent number
US04804662

Reaction notes

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