Hydrochloric Acid → HCID 21275430, compound

HRID 1381962Notes

Reaction equation

HRID 1381962 reaction equation
C(OC([N:8]1[CH2:25][CH2:24][C:11]2([C:15](=[O:16])[N:14]([O:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])[C:13](=[O:23])[CH2:12]2)[CH2:10][CH2:9]1)=O)(C)(C)C.CO.[ClH:28]>FC(F)(F)C(O)=O>[ClH:28].[CH3:22][O:21][C:19]([CH2:18][O:17][N:14]1[C:13](=[O:23])[CH2:12][C:11]2([CH2:24][CH2:25][NH:8][CH2:9][CH2:10]2)[C:15]1=[O:16])=[O:20]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887Methanol2×HCID 21275437HCID 21275437, compound

Product 1

HCID 21275430HCID 21275430, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

In trifluoroacetic acid (3 ml) was dissolved 8-tert-butyloxycarbonyl-2-methoxycarbonylmethyloxy-2,8-diazaspiro[4,5]decane-1,3-dione (0.5 g), and the solution was left standing at room temperature for 10 minutes. To the solution was added methanol (20 ml), to which was added 2 ml of a methanol solution of 1N hydrogen chloride. The solvent was evaporated off under reduced pressure, and the residual oil was crystallized from ether-methanol to obtain 0.32 g of a coloress solid, m.p. 174° to 178° C.

Workup

  1. waitthe solution was left
  2. customThe solvent was evaporated off under reduced pressure
  3. customthe residual oil was crystallized from ether-methanol
  4. customto obtain 0.32 g of a coloress solid, m.p. 174° to 178° C.

Sources & evidence

ORD record
ord-a2b833f5bb9d4c879b067fdfa77b4b0e
Source dataset
uspto-grants-1989_02
Patent number
US04804665

Reaction notes

Loading…