Potassium Carbonate → 3-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-6,7,8-trifluoro-, ethyl ester

HRID 1382000Notes

Reaction equation

HRID 1382000 reaction equation
C(OC(CC[NH:8][CH:9]=[C:10]([C:16](=[O:27])[C:17]1[CH:22]=[C:21]([F:23])[C:20]([F:24])=[C:19]([F:25])[C:18]=1F)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=O)C.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[F:25][C:19]1[CH:18]=[C:17]2[C:22](=[C:21]([F:23])[C:20]=1[F:24])[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:16]2[OH:27]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 178472019HCID 178472019, compound

Product 1

HCID 27339723-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-6,7,8-trifluoro-, ethyl ester

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

7.7 g of the compound from Example 6 and 2.9 g of K2CO3 are heated at 140°-5° C. for 4 hours in 36 ml of DMF. The mixture is subsequently poured onto ice and acidified, and the precipitated solid is separated off and dried.

Workup

  1. additionThe mixture is subsequently poured onto ice
  2. customthe precipitated solid is separated off
  3. customdried

Sources & evidence

ORD record
ord-0553b6a3fcc44f2ca6ffbcb4079de1d1
Source dataset
uspto-grants-1989_02
Patent number
US04804760

Reaction notes

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