反应详情

To the product of step A (1.56 g) in THF (12 mL) was added methanol (3 mL) and Cs2CO3. The reaction stirred overnight at room temperature before it was diluted with EtOAc and washed with saturated aqueous NaHCO3 solution. The concentrated residue was purified by flash chromatography on silica gel with an EtOAc/hexane gradient elution affording the title compound. HPLC/MS: 499.8 (M+1), 501.8 (M+3); Rt=3.95 min.

1. washwashed with saturated aqueous NaHCO3 solution
2. customThe concentrated residue was purified by flash chromatography on silica gel with an EtOAc/hexane gradient elution