Hydrazine hydrate (1:1) → HCID 14581294, compound

HRID 1382203Notes

Reaction equation

HRID 1382203 reaction equation
[N:1]1([C:6]2[CH:23]=[CH:22][C:9]([C:10]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][C:17]=3[C:18](OC)=[O:19])=O)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.O.[NH2:25][NH2:26]>CCO>[N:1]1([C:6]2[CH:23]=[CH:22][C:9]([C:10]3[C:12]4[CH:13]=[N:14][CH:15]=[CH:16][C:17]=4[C:18](=[O:19])[NH:26][N:25]=3)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 14581300HCID 14581300, compound

Product 1

HCID 14581294HCID 14581294, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 0.43 g (1.4 mmol) of 3-[4-(1H-imidazol-1-yl)benzoyl]-4-carbomethoxypyridine in 50 mL of EtOH is treated with hydrazine monohydrate (0.08 g, 1.54 mmol) and heated to reflux for 1 day. The mixture is allowed to cool and the white solid precipitate filtered and dried to produce 4-[4-(1H-imidazol-1-yl)phenyl]-1-oxo-1,2-dihydropyrido[3,4-d]pyridazine. M.P. 377° C. dec.

Workup

  1. temperatureheated
  2. temperatureto reflux for 1 day
  3. temperatureto cool
  4. filtrationthe white solid precipitate filtered
  5. customdried

Sources & evidence

ORD record
ord-ba86c11bc71640c98822c352e4ca88e0
Source dataset
uspto-grants-1989_02
Patent number
US04806535

Reaction notes

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